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OSIS or variant may refer to:
The suffix -osis is used for forming a number of medical terms. The suffix itself signifies only a general functional disorder, but the constructed words are more specific. It is often used to denote a biological process (i.e. Apoptosis, Phagocytosis, Necrosis...)
Osis (feminine: Ose), is a Latvian language surname meaning "ash" (tree; Fraxinus excelsior)